Ru(II)/bisphosphine/diimine/amino acid complexes: diastereoisomerism, cytotoxicity, and inhibition of tumor cell adhesion to collagen type I

Autor(es)

Dos Santos, Edjane R. ; Correa, Rodrigo S. ; Ribeiro, Juliana U. ; Graminha, Angelica E. ; Ellena, Javier ; Selistre-de-Araujo, Heloisa S. ; Batista, Alzir A.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Coordination Chemistry; v. 69, n. 23, p. 3518-3530, 2016.
• Citações Web of Science: 6

Resumo

We herein report the synthesis and characterization of Ru(II)/amino acid complexes with general formula {[}Ru(AA-H)(dppb)(4-mebipy)](PF6), where AA-H means the deprotonated amino acids Gly, Ala, Val, Met, Trp, Tyr, and Ser; dppb is 1,4-bis(diphenylphosphino)butane and 4-mebipy=4,4-dimethyl-2,2-bipyridine. The complexes were characterized by P-31[H-1], C-13, and H-1 NMR spectroscopy, as well as X-ray crystallographic analysis of {[}Ru(DL-Ala-H)(dppb)(4-mebipy)](+), suggesting the presence of diastereoisomers. The complexes exhibit IC50 values against breast tumor cells (MDA-MB-231) comparable with cisplatin. In addition, the Ru(II)-based complex with tryptophan inhibited tumor cell adhesion to collagen type I. Therefore, the use of ruthenium complexes containing amino acids can be an interesting tool for development of new therapeutic agents. {[}GRAPHICS] . (AU)

• Processo FAPESP: 12/06013-4 - Estudo da expressão de genes de apoptose, ciclo celular, reparo do DNA e estresse oxidativo em células de carcinoma de pulmão humano tratadas com complexos de fórmula geral [Ru(AA)(dppb)(bipy)]PF6
• Beneficiário: Alzir Azevedo Batista
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/26559-4 - Modificações estruturais em complexos de Ru(II) biologicamente ativos para o desenho de novos candidatos a metalofármacos
• Beneficiário: Rodrigo de Souza Corrêa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado