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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Role of UCP2 polymorphisms on dietary intake of obese patients who underwent bariatric surgery

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Autor(es):
Nicoletti, C. F. ; Kimura, B. M. ; de Oliveira, B. A. P. ; de Pinhel, M. A. S. ; Salgado, W. ; Marchini, J. S. ; Nonino, C. B.
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: CLINICAL OBESITY; v. 6, n. 5, p. 354-358, OCT 2016.
Citações Web of Science: 1
Resumo

Uncoupling protein 2 (UCP2) plays an important role in body weight and energy metabolism and may be related to the control of food consumption. This study aimed to investigate the contribution of UCP2 gene variants on the dietary intake on a population after bariatric surgery. This study enrolled 150 obese patients (body mass index >= 35kg m(-2)) who submitted to Roux-en-Y gastric bypass. Weight (kg), BMI (kg m(-2)), energy (kcal d-1) and macronutrients intake (g d(-1)) of preoperative and 1-year postoperative period were collected from medical records. Ala55Val and -866G>A polymorphisms in the UCP2 gene were genotyped through allelic discrimination method in real-time polymerase chain reaction using the TaqMan pre-designed SNP Genotyping Assays kits. Hardy-Weinberg equilibrium, t-test and regression models were performed in statistical analysis (P < 0.05). We found an allelic frequency of 0.44 for allele Val and 0.41 for allele A. In the postoperative period, patients with at least one rare allele for polymorphisms and with at least one rare allele for both polymorphisms together (haplotype) present a greater energy and carbohydrate intake, even after adjusting for gender, age and weight. Genetic variants in UCP2 gene were associated with the dietary consumption after Roux-En-Y gastric bypass. (AU)

Processo FAPESP: 12/05539-2 - Identificação de polimorfismos genéticos com impacto nas alterações ponderais e bioquímicas de indivíduos obesos após derivação gástrica em Y de Roux
Beneficiário:Carla Barbosa Nonino
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/03623-6 - Identificação de polimorfismos genéticos com impacto nas alterações ponderais e bioquímicas de indivíduos obesos após derivação gástrica em Y de Roux
Beneficiário:Carolina Nicoletti Ferreira Fino
Linha de fomento: Bolsas no Brasil - Doutorado