Antimelanoma effect of Salmonella Typhimurium integration host factor mutant in murine model

Autor(es)

Werle, Catierine Hirsch ; Damiani, Igor ; Milanez, Guilherme Paier ; Farias, Alessandro S. ; Cintra Gomes Marcondes, Maria Cristina ; Culler, Hebert Fabricio ; Sircili, Marcelo Palma ; Leite, Bruna ; Brocchi, Marcelo

• Tipo de documento: Artigo Científico
• Fonte: FUTURE ONCOLOGY; v. 12, n. 20, p. 2367-2378, OCT 2016.
• Citações Web of Science: 0

Resumo

Aim: This study aimed to evaluate an attenuated Salmonella ihfA-null mutant strain as therapeutic agent to control tumor growth. Materials \& methods: After bacterial toxicity evaluation, C57BL/6JUnib mice were inoculated with B16F10 cells and treated with two Salmonella strains (LGBM 1.1 and LGBM 1.41). Results: LGBM 1.1 can reduce tumor mass, but it exerts some toxic effects. Although LGBM 1.41 is less toxic than LGBM 1.1, it does not reduce tumor mass significantly. Indeed, animals treated with LGBM 1.41 present only slightly initial delay in tumor progression and increased survival rate as compared with the control. Conclusion: The null-mutants of ihfA gene of Salmonella Typhimurium could be a promising candidate for melanoma treatment. (AU)

• Processo FAPESP: 12/25426-8 - Formação de biofilmes em diferentes mutantes nulos de Salmonella enterica.
• Beneficiário: Bruna Leite Simioni
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/05382-6 - Avaliação da virulência e expressão gênica diferencial in vivo de Salmonella enterica mutantes para proteínas associadas ao nucleóide.
• Beneficiário: Guilherme Paier Milanez
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/13412-8 - Salmonella enterica: importância de NAPS na patogenicidade e atenuação da virulência
• Beneficiário: Marcelo Brocchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular