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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimelanoma effect of Salmonella Typhimurium integration host factor mutant in murine model

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Author(s):
Werle, Catierine Hirsch ; Damiani, Igor ; Milanez, Guilherme Paier ; Farias, Alessandro S. ; Cintra Gomes Marcondes, Maria Cristina ; Culler, Hebert Fabricio ; Sircili, Marcelo Palma ; Leite, Bruna ; Brocchi, Marcelo
Total Authors: 9
Document type: Journal article
Source: FUTURE ONCOLOGY; v. 12, n. 20, p. 2367-2378, OCT 2016.
Web of Science Citations: 0
Abstract

Aim: This study aimed to evaluate an attenuated Salmonella ihfA-null mutant strain as therapeutic agent to control tumor growth. Materials \& methods: After bacterial toxicity evaluation, C57BL/6JUnib mice were inoculated with B16F10 cells and treated with two Salmonella strains (LGBM 1.1 and LGBM 1.41). Results: LGBM 1.1 can reduce tumor mass, but it exerts some toxic effects. Although LGBM 1.41 is less toxic than LGBM 1.1, it does not reduce tumor mass significantly. Indeed, animals treated with LGBM 1.41 present only slightly initial delay in tumor progression and increased survival rate as compared with the control. Conclusion: The null-mutants of ihfA gene of Salmonella Typhimurium could be a promising candidate for melanoma treatment. (AU)

FAPESP's process: 12/25426-8 - Biofilm formation in different null mutants of Salmonella enterica
Grantee:Bruna Leite Simioni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/05382-6 - Virulence evaluation and Differential gene expression in vivo of Salmonella enterica mutants for nucleoid associated proteins
Grantee:Guilherme Paier Milanez
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/13412-8 - Salmonella enterica: roles of NAPS in pathogenicity and virulence
Grantee:Marcelo Brocchi
Support type: Regular Research Grants