Antimelanoma effect of Salmonella Typhimurium integration host factor mutant in murine model

Author(s)

Werle, Catierine Hirsch ; Damiani, Igor ; Milanez, Guilherme Paier ; Farias, Alessandro S. ; Cintra Gomes Marcondes, Maria Cristina ; Culler, Hebert Fabricio ; Sircili, Marcelo Palma ; Leite, Bruna ; Brocchi, Marcelo

• Document type: Journal article
• Source: FUTURE ONCOLOGY; v. 12, n. 20, p. 2367-2378, OCT 2016.
• Web of Science Citations: 0

Abstract

Aim: This study aimed to evaluate an attenuated Salmonella ihfA-null mutant strain as therapeutic agent to control tumor growth. Materials \& methods: After bacterial toxicity evaluation, C57BL/6JUnib mice were inoculated with B16F10 cells and treated with two Salmonella strains (LGBM 1.1 and LGBM 1.41). Results: LGBM 1.1 can reduce tumor mass, but it exerts some toxic effects. Although LGBM 1.41 is less toxic than LGBM 1.1, it does not reduce tumor mass significantly. Indeed, animals treated with LGBM 1.41 present only slightly initial delay in tumor progression and increased survival rate as compared with the control. Conclusion: The null-mutants of ihfA gene of Salmonella Typhimurium could be a promising candidate for melanoma treatment. (AU)

• FAPESP's process: 12/25426-8 - Biofilm formation in different null mutants of Salmonella enterica
• Grantee: Bruna Leite Simioni
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 12/05382-6 - Virulence evaluation and Differential gene expression in vivo of Salmonella enterica mutants for nucleoid associated proteins
• Grantee: Guilherme Paier Milanez
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 14/13412-8 - Salmonella enterica: roles of NAPS in pathogenicity and virulence
• Grantee: Marcelo Brocchi
• Support Opportunities: Regular Research Grants