Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals

Autor(es)

Botezelli, Jose D. ; Coope, Andressa ; Ghezzi, Ana C. ; Cambri, Lucieli T. ; Moura, Leandro P. ; Scariot, Pedro P. M. ; Gaspar, Rodrigo Stellzer ; Mekary, Rania A. ; Ropelle, Eduardo Rochete ; Pauli, Jose Rodrigo

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 6, AUG 4 2016.
• Citações Web of Science: 16

Resumo

The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8-14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises). After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, and inflammation were evaluated and analyzed. The strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipid contents than other protocols (all P < 0.05). All three exercise protocols induced a remarkable reduction in inflammation, tissue triglyceride content, and inflammatory pathways, which was achieved through c-Jun NH2-terminal kinase (JNK) phosphorylation and factor nuclear kappa B (NFkB) activation in both the liver and the muscle. Our data suggest that strength training reduced the severity of most of the metabolic disorders induced by a fructose-rich diet and could be the most effective strategy to prevent or treat fructose-induced metabolic diseases. (AU)

• Processo FAPESP: 13/21491-2 - Papel do exercício físico na regulação da proteína rock e seus efeitos sobre a sinalização da insulina em músculo esquelético e fígado de camundongos obesos
• Beneficiário: José Rodrigo Pauli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/20293-2 - Efeitos do exercício de endurance e de força nas vias de captação de glicose em camundongos nocaute heterozigotos GLUT4
• Beneficiário: José Diego Botezelli
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/14380-8 - Strength training prevents hyperinsulinemia, insulin resistance, and inflammation independent of weight loss in fructose-fed animals
• Beneficiário: José Rodrigo Pauli
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo