Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals

Author(s)

Botezelli, Jose D. ; Coope, Andressa ; Ghezzi, Ana C. ; Cambri, Lucieli T. ; Moura, Leandro P. ; Scariot, Pedro P. M. ; Gaspar, Rodrigo Stellzer ; Mekary, Rania A. ; Ropelle, Eduardo Rochete ; Pauli, Jose Rodrigo

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 6, AUG 4 2016.
• Web of Science Citations: 16

Abstract

The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8-14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises). After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, and inflammation were evaluated and analyzed. The strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipid contents than other protocols (all P < 0.05). All three exercise protocols induced a remarkable reduction in inflammation, tissue triglyceride content, and inflammatory pathways, which was achieved through c-Jun NH2-terminal kinase (JNK) phosphorylation and factor nuclear kappa B (NFkB) activation in both the liver and the muscle. Our data suggest that strength training reduced the severity of most of the metabolic disorders induced by a fructose-rich diet and could be the most effective strategy to prevent or treat fructose-induced metabolic diseases. (AU)

• FAPESP's process: 13/21491-2 - Role of physical exercise in regulation of rock protein and the effects on insulin signaling in skeletal muscle and liver in obese mice
• Grantee: José Rodrigo Pauli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/20293-2 - Effects of endurance and strength exercises on the glucose uptake pathways in knockout heterozygous GLUT4 mice
• Grantee: José Diego Botezelli
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/14380-8 - Strength training prevents hyperinsulinemia, insulin resistance, and inflammation independent of weight loss in fructose-fed animals
• Grantee: José Rodrigo Pauli
• Support Opportunities: Regular Research Grants - Publications - Scientific article