| Texto completo | |
| Autor(es): Mostrar menos - |
Hashim, D.
;
Sartori, S.
;
Brennan, P.
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Curado, M. P.
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Wunsch-Filho, V.
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Divaris, K.
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Olshan, A. F.
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Zevallos, J. P.
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Winn, D. M.
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Franceschi, S.
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Castellsague, X.
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Lissowska, J.
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Rudnai, P.
;
Matsuo, K.
;
Morgenstern, H.
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Chen, C.
;
Vaughan, T. L.
;
Hofmann, J. N.
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D'Souza, G.
;
Haddad, R. I.
;
Wu, H.
;
Lee, Y. -C.
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Hashibe, M.
;
La Vecchia, C.
;
Boffetta, P.
Número total de Autores: 25
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| Tipo de documento: | Artigo Científico |
| Fonte: | Annals of Oncology; v. 27, n. 8, p. 1619-1625, AUG 2016. |
| Citações Web of Science: | 23 |
| Resumo | |
This pooled analysis describes the largest and most comprehensive assessment of the association between oral hygiene indicators and HNCs to date, including oral cavity, laryngeal, hypopharyngeal, and oropharyngeal cancers. We found good oral hygiene is associated with lower risk of HNC. Improvements in oral hygiene by increasing oral hygiene literacy, particularly for annual dentist visits and daily tooth brushing, may be protective against HNC.Poor oral hygiene has been proposed to contribute to head and neck cancer (HNC) risk, although causality and independency of some indicators are uncertain. This study investigates the relationship of five oral hygiene indicators with incident HNCs. In a pooled analysis of 8925 HNC cases and 12 527 controls from 13 studies participating in the International Head and Neck Cancer Epidemiology Consortium, comparable data on good oral hygiene indicators were harmonized. These included: no denture wear, no gum disease (or bleeding), < 5 missing teeth, tooth brushing at least daily, and visiting a dentist a parts per thousand yenonce a year. Logistic regression was used to estimate the effects of each oral hygiene indicator and cumulative score on HNC risk, adjusting for tobacco smoking and alcohol consumption. Inverse associations with any HNC, in the hypothesized direction, were observed for < 5 missing teeth {[}odds ratio (OR) = 0.78; 95% confidence interval (CI) 0.74, 0.82], annual dentist visit (OR = 0.82; 95% CI 0.78, 0.87), daily tooth brushing (OR = 0.83, 95% CI 0.79, 0.88), and no gum disease (OR = 0.94; 95% CI 0.89, 0.99), and no association was observed for wearing dentures. These associations were relatively consistent across specific cancer sites, especially for tooth brushing and dentist visits. The population attributable fraction for a parts per thousand currency sign 2 out of 5 good oral hygiene indicators was 8.9% (95% CI 3.3%, 14%) for oral cavity cancer. Good oral hygiene, as characterized by few missing teeth, annual dentist visits, and daily tooth brushing, may modestly reduce the risk of HNC. (AU) | |
| Processo FAPESP: | 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe |
| Beneficiário: | José Eluf Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |