Genetics and metabolic deregulation following cancer initiation: A world to explore

Autor(es)

Araldi, Rodrigo Pinheiro ; Modolo, Diego Grando ; de Sa Junior, Paulo Luiz ; Consonni, Silvio Roberto ; de Carvalho, Rodrigo Franco ; Roperto, Franco Peppino ; Becak, Willy ; Stocco, Rita de Cassia

• Tipo de documento: Artigo de Revisão
• Fonte: BIOMEDICINE & PHARMACOTHERAPY; v. 82, p. 449-458, AUG 2016.
• Citações Web of Science: 5

Resumo

Cancer is a group of highly complex and heterogeneous diseases with several causes. According to the stochastic model, cancer initiates from mutation in somatic cells, leading to genomic instability and cell transformation. This canonical pathway of carcinogenesis is related to the discovery of important mechanisms that regulate cancer initiation. However, there are few studies describing genetic and metabolic alterations that deregulate transformed cells, resulting in epithelial-mesenchymal transition (EMT) and its most dramatic consequence, the metastasis. This review summarizes the main genetics and metabolic changes induced by reactive oxygen species (ROS) that lead to EMT. (C) 2016 Elsevier Masson SAS. All rights reserved. (AU)

• Processo FAPESP: 14/20617-5 - Estudo da ação do papilomavírus bovino (BPV) na transição epitélio-mesênquima
• Beneficiário: Rodrigo Pinheiro Araldi
• Modalidade de apoio: Bolsas no Brasil - Doutorado