Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetics and metabolic deregulation following cancer initiation: A world to explore

Full text
Author(s):
Araldi, Rodrigo Pinheiro ; Modolo, Diego Grando ; de Sa Junior, Paulo Luiz ; Consonni, Silvio Roberto ; de Carvalho, Rodrigo Franco ; Roperto, Franco Peppino ; Becak, Willy ; Stocco, Rita de Cassia
Total Authors: 8
Document type: Review article
Source: BIOMEDICINE & PHARMACOTHERAPY; v. 82, p. 449-458, AUG 2016.
Web of Science Citations: 5
Abstract

Cancer is a group of highly complex and heterogeneous diseases with several causes. According to the stochastic model, cancer initiates from mutation in somatic cells, leading to genomic instability and cell transformation. This canonical pathway of carcinogenesis is related to the discovery of important mechanisms that regulate cancer initiation. However, there are few studies describing genetic and metabolic alterations that deregulate transformed cells, resulting in epithelial-mesenchymal transition (EMT) and its most dramatic consequence, the metastasis. This review summarizes the main genetics and metabolic changes induced by reactive oxygen species (ROS) that lead to EMT. (C) 2016 Elsevier Masson SAS. All rights reserved. (AU)

FAPESP's process: 14/20617-5 - Study of the action of bovine papillomavirus (BPV) in epithelial-mesenchymal transition
Grantee:Rodrigo Pinheiro Araldi
Support Opportunities: Scholarships in Brazil - Doctorate