Structure, Regulation and Function of Gap Junctions in Liver

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Willebrords, Joost ; Yanguasa, Sara Crespo ; Maes, Michael ; Decrock, Elke ; Wang, Nan ; Leybaert, Luc ; da Silva, Tereza Cristina ; Alves Pereira, Isabel Veloso ; Jaeschke, Hartmut ; Cogliati, Bruno ; Vinken, Mathieu

• Tipo de documento: Artigo de Revisão
• Fonte: CELL COMMUNICATION AND ADHESION; v. 22, n. 2-6, p. 29-37, 2015.
• Citações Web of Science: 3

Resumo

Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular communication between cells. They arise from the interaction of two hemichannels of adjacent cells, which in turn are composed of six connexin proteins. In liver, gap junctions are predominantly found in hepatocytes and play critical roles in virtually all phases of the hepatic life cycle, including cell growth, differentiation, liver-specific functionality and cell death. Liver gap junctions are directed through a broad variety of mechanisms ranging from epigenetic control of connexin expression to post-translational regulation of gap junction activity. This paper reviews established and novel aspects regarding the architecture, control and functional relevance of liver gap junctions. (AU)

• Processo FAPESP: 13/50420-6 - Canais de conexina e panexina como alvos terapêuticos e biomarcadores nas doenças hepáticas aguda e crônica
• Beneficiário: Mathieu Frederick Alexander Vinken
• Modalidade de apoio: Auxílio à Pesquisa - Programa SPEC