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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases

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Autor(es):
de Queiroz, Matheus Trovao ; Pereira, Vanessa Goncalves ; do Nascimento, Cinthia Castro ; D'Almeida, Vania
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN ENDOCRINOLOGY; v. 7, SEP 21 2016.
Citações Web of Science: 0
Resumo

Non-coding RNAs (ncRNAs) are a functional class of RNA involved in the regulation of several cellular processes which may modulate disease onset, progression, and prognosis. Lysosomal storage diseases (LSD) are a group of rare disorders caused by mutations of genes encoding specific hydrolases or non-enzymatic proteins, characterized by a wide spectrum of manifestations. The alteration of ncRNA levels is well established in several human diseases such as cancer and auto-immune disorders; however, there is a lack of information focused on the role of ncRNA in rare diseases. Recent reports related to changes in ncRNA expression and its consequences on LSD physiopathology show us the importance to keep advancing in this field. This article will summarize recent findings and provide key points for further studies on LSD and ncRNA association. (AU)

Processo FAPESP: 14/14230-0 - Análise de microRNAs em estruturas encefálicas no modelo animal da mucopolissacaridose tipo I
Beneficiário:Vanessa Gonçalves Pereira
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado