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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of classic ketogenic diet treatment on lipoprotein subfractions in children and adolescents with refractory epilepsy

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Autor(es):
de Lima, Patricia Azevedo ; Prudencio, Mariana Baldini ; Murakami, Daniela Kawamoto ; de Brito Sampaio, Leticia Pereira ; Figueiredo Neto, Antonio Martins ; Teixeira Damasceno, Nagila Raquel
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: NUTRITION; v. 33, p. 271-277, JAN 2017.
Citações Web of Science: 4
Resumo

Objective: The aim of this study was to evaluate the effects of the classic ketogenic diet (KD) on low density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions in children and adolescents with refractory epilepsy. Methods: This prospective study recruited children and adolescents of either sex, whose epilepsy was refractory to treatment with multiple drugs. To be included, the patient had to have an indication for treatment with the KD and be treated as an outpatient. At baseline and after 3 and 6 mo of the KD, lipid profile (total cholesterol {[}TC], triacylglycerols {[}TG], LDL cholesterol {[}LDL-C], and HDL cholesterol {[}HDL-C]), apolipoproteins (apoA-I and apoB), 10 subfractions of HDL, 7 sub-fractions of LDL, LDL phenotype, and LDL size were analyzed using the Lipoprint system. Results: The lipid profile components (TC, TG, LDL-C, HDL-C, apoA-I, and apoB) increased during the 3-mo follow-up, and remained consistent after 6 mo of treatment. Similarly, non-HDL-C, TC/HDL-C, LDL-C/HDL-C, and apoB/apoA-I ratios, representing atherogenic particles, significantly increased. In contrast, qualitative lipoprotein characteristics progressively changed during the follow-up period. Small LDL subfractions increased, and this profile was related with reduced LDL size (27.3 nm to 26.7 nm). The LDL phenotype became worse; 52.1% of the patients had a non-A phenotype after 6 mo of the KD. Small HDL subfractions decreased only after 6 mo of the KD. Conclusions: KD treatment promotes negative changes in lipoprotein size and phenotype, contributing to atherogenic risk in these patients. (C) 2016 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 14/26094-4 - Dieta cetogênica clássica e modificada: avaliação do potencial terapêutico e impacto sobre o perfil oxidativo, lipidômico, inflamatório e tamanho de lipoproteínas em crianças e adolescentes com epilepsia refratária
Beneficiário:Patricia Azevedo de Lima
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 11/13616-4 - Propriedades ópticas e estruturais de elastômeros e fluidos complexos de interesse biológico
Beneficiário:Antonio Martins Figueiredo Neto
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 12/20789-5 - Estudo de inadequação de consumo de macro e micronutrientes em crianças e adolescentes sob tratamento dietético para epilepsia refratária
Beneficiário:Mariana Baldini Prudencio
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 12/03775-0 - Impacto da dieta cetogênica nas características oxidativas, físicas e lipídicas de lipoproteínas de crianças com epilepsia refratária
Beneficiário:Patricia Azevedo de Lima
Linha de fomento: Bolsas no Brasil - Mestrado