Oral health, diabetes, and body weight

Autor(es)

Angelo Cintra, Luciano Tavares ; Samuel, Renata Oliveira ; Carrara Prieto, Annelise Katrine ; Sumida, Doris Hissako ; Dezan-Junior, Eloi ; Gomes-Filho, Joao Eduardo

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 73, p. 94-99, JAN 2017.
• Citações Web of Science: 9

Resumo

Objectives: The effects of apical periodontitis (AP) and periodontal disease (PD) on organ weights in rats with diabetes mellitus (DM) were evaluated. Design: Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into eight groups of ten: normoglycemic (N), AP, PD, AP + PD, DM, DM + AP, DM + PD, and DM + AP + PD. DM was induced by streptozotocin; AP, by dental exposure to the oral environment; and PD, by periodontal ligature. Blood glucose concentration was measured at 0, 6,15, and 35 days; body weight, measured daily; and animals were sacrificed after 30 days after induction of oral infections. Liver, kidney, pancreas, brain, heart, lungs, and gonads were each weighed. Glycemia, feed intake, organ weight, and body weight were subjected to statistical analyses (p < 0.05). Results: Glycemic levels were higher in all diabetic groups after day 6, but were consistently similar in normoglycemic groups. Blood glucose was higher in DM + PD and DM + AP + PD groups than in the DM group at days 15 and 35. The feed intake was similar among all groups. Brain, heart, and gonad weights were significantly increased in DM + AP + PD. Kidney and lung weights were increased in DM, regardless of the presence of oral infections. Liver weight was reduced in AP and/or PD. Pancreas weight was reduced in DM, independent of AP or PD. Among the normoglycemic groups, there were no significant differences among organ weights. Conclusion: Apical periodontitis and periodontal disease may potentiate the adverse effects of diabetes. (C) 2016 Published by Elsevier Ltd. (AU)

• Processo FAPESP: 12/02083-8 - Influência da infecção pulpar associada à diabetes no perfil sanguíneo e na quantificação das citocinas pró-inflamatórias TNF-±, IL-6, IL-17. Análise histológica, hematológica e em órgãos de ratos Wistar.
• Beneficiário: Luciano Tavares Angelo Cintra
• Modalidade de apoio: Auxílio à Pesquisa - Regular