Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RDRio genotype

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Eloise Brasil Moraes ; Letícia Slompo ^[2] ; Amanda Juliane Finardi ; Heloisa Paro Pedro da Silveira ^[4] ; Luciana Ruiz ^[5] ; Harrison Magdinier Gomes ^[6] ; Virginia Bodelão Richini ^[7] ; Philip Suffys ^[8] ; Carlos Magno Castelo Branco Fortaleza ^[9] ; Ricardo Cavalcanti ^[10] ; Ida Maria Foschiani Dias Baptista

• Tipo de documento: Artigo Científico
• Fonte: Memórias do Instituto Oswaldo Cruz; v. 112, n. 3, p. 182-187, 2017-02-16.

Resumo

BACKGROUND Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RDRio. The strain has been associated with different characteristics of the disease. OBJECTIVES In the present study we investigated the association of epidemiological, clinical, radiological and bacteriological variables with pulmonary tuberculosis caused by RDRioMycobacterium tuberculosis strain in large regions of São Paulo. METHODS We conducted a cross-sectional study in 530 patients with pulmonary tuberculosis, diagnosed using sputum culture, from two regions of the São Paulo state in Brazil. The samples were brought to São Paulo reference laboratories for epidemiological, clinical, radiological and bacteriological analyses, and the data were obtained from a TB notification system. RDRio genotyping and Spoligotyping of the samples were performed. For the analysis of the categorical variables we used the chi-square test or the Fisher’s exact test, and for the continuous variables, the Mann-Whitney test. In addition, a logistic regression was used for multivariate analysis. Differences with p < 0.05 were considered significant. FINDINGS The RDRio deletion was identified in 152 (28.7%) samples. In the univariate analysis, both the age groups above 25 years and alcohol consumption were associated with the RDRio deletion. The multivariate analysis confirmed the association of the RDRio deletion with the age groups: 25-35 years old [OR: 2.28 (1.02-5.07; p = 0.04)] and 36-60 years old (OR: 2.36 (1.11-5.05); p = 0.03], and also with alcohol consumption [OR: 1.63 (1.05-2.54); p = 0,03]. MAIN CONCLUSIONS In this study, we identified new factors associated with the M. tuberculosis of the RDRio deletion strains infection. (AU)

• Processo FAPESP: 13/09538-3 - Epidemiologia molecular e estudo da diversidade genética da tuberculose no Estado de São Paulo
• Beneficiário: Ida Maria Foschiani Dias Baptista
• Modalidade de apoio: Auxílio à Pesquisa - Regular