Reduced Aerobic Capacity and Quality of Life in Physically Inactive Patients With Systemic Lupus Erythematosus With Mild or Inactive Disease

Autor(es)

Pinto, Ana J. ; Miyake, Cintia N. H. ; Benatti, Fabiana B. ; Silva, Clovis A. ; Sallum, Adriana M. E. ; Borba, Eduardo ; de Sa-Pinto, Ana L. ; Bonfa, Eloisa ; Gualano, Bruno

• Tipo de documento: Artigo Científico
• Fonte: ARTHRITIS CARE & RESEARCH; v. 68, n. 12, p. 1780-1786, DEC 2016.
• Citações Web of Science: 12

Resumo

Objective. To compare aerobic capacity and health-related quality of life (HRQOL) in physically inactive adult systemic lupus erythematosus (A-SLE) and childhood-onset systemic lupus erythematosus (C-SLE) patients with mild/inactive disease versus healthy controls. Methods. In a cross-sectional study, 39 patients (C-SLE: n=18, ages 9-18 years; and A-SLE: n=21, ages 23-45 years) with inactive disease activity (Systemic Lupus Erythematosus Disease Activity Index <= 4) and low cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index <= 2) and 30 healthy controls (15 children and adolescents {[}C-CTRL], 15 adults {[}A-CTRL]) matched by physical inactivity, age, sex, and body mass index (BMI) were assessed for aerobic capacity and HRQOL. Results. All participants were considered physically inactive according to physical activity guidelines. C-SLE and A-SLE patients showed lower V-O2peak (95% CI confidence interval {[}95% CI] -10.5, -1.2 and -11.1, -3.8, respectively) and higher time-to-exhaustion when compared with C-CTRL and A-CTRL (95% CI -2.8, 0.1 and -3.9, -1.7, respectively). C-SLE patients showed significantly lower scores in scholar functioning from the Pediatric Quality of Life Inventory questionnaire (P<0.05) whereas A-SLE patients showed lower scores in most domains of the Short Form 36 health survey questionnaire (physical function, role-physical, bodily pain, general health, vitality, social function, and mental health) when compared with healthy controls (P<0.05 for all). Conclusion. Our study provides novel data suggesting that A-SLE and C-SLE patients with mild/inactive disease have impaired aerobic capacity and HRQOL when compared with controls matched by physical inactivity, age, sex, and BMI. These findings reinforce the recommendation of physical activity in SLE treatment. (AU)

• Processo FAPESP: 11/24093-2 - Efeito do exercício físico aeróbio no perfil inflamatório e na sensibilidade à insulina de pacientes com lúpus eritematoso sistêmico
• Beneficiário: Eloisa Silva Dutra de Oliveira Bonfá
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/13126-2 - Avaliação do nível de atividade física em pacientes com Dermatomiosite juvenil e Lúpus eritematoso sistêmico juvenil
• Beneficiário: Ana Jéssica Pinto
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 10/18708-1 - Eficácia e segurança da suplementação de cretaina em pacientes com dermatomiosite de início juvenil e lúpus eritematoso sistêmico de início juvenil
• Beneficiário: Bruno Gualano
• Modalidade de apoio: Auxílio à Pesquisa - Regular