Mutation in the S Gene a Determinant of the Hepatitis B Virus Associated With Concomitant HBsAg and Anti-HBs in a Population in Northeastern Brazil

Autor(es)

Albuquerque, Ingrid de Campos ; Sousa, Marinilde Teles ; Cruz Santos, Max Diego ; Costa Nunes, Jomar Diogo ; Diniz Moraes, Maria Joselia ; Gomes-Gouvea, Michele Soares ; Rebelo Pinho, Joao Renato ; Carrilho, Flair Jose ; Barros Fonseca, Lena Maria ; Paiva Ferreira, Adalgisa de Sousa

• Tipo de documento: Artigo Científico
• Fonte: Journal of Medical Virology; v. 89, n. 3, p. 458-462, MAR 2017.
• Citações Web of Science: 2

Resumo

Mutations in the a determinant of S gene may develop co-existence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) in the serum of infected hepatitis B virus (HBV) individuals. Mutations in this region may change the antigenicity of HBsAg, which in turn, lead to escape of neutralizing action of anti-HBs antibodies. This study identified individuals with concomitant HBsAg and anti-HBs serological markers in individuals of Maranhao, Northeastern Brazil. Samples from a population-based study were evaluated for HBsAg, anti-HBs, and anti-HBc, and those that tested positive for simultaneous HBsAg and anti-HBs were submitted to HBV DNA quantification and S gene characterization by Sanger sequencing. Mutations were investigated in the a determinant located in major hydrophilic region (MHR) of the S gene. Among 3,984 samples analyzed, 92 (2.3%) were positive for HBsAg and three had the atypical HBsAg and anti-HBs-positive profile (3.26%). The frequency of HBsAg and anti-HBs co-existence was similar to previous studies. Only one individual harbored mutation in the S gene a determinant associated with this profile. Little is known about this phenomenon; however, studies as ours may contribute for future enlightenment of this important issue. (C) 2016 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 09/53946-3 - EMU: aquisição de analisador genético de DNA para o sequenciamento automático de DNA
• Beneficiário: João Renato Rebello Pinho
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários