| Full text | |
| Author(s): |
Albuquerque, Ingrid de Campos
;
Sousa, Marinilde Teles
;
Cruz Santos, Max Diego
;
Costa Nunes, Jomar Diogo
;
Diniz Moraes, Maria Joselia
;
Gomes-Gouvea, Michele Soares
;
Rebelo Pinho, Joao Renato
;
Carrilho, Flair Jose
;
Barros Fonseca, Lena Maria
;
Paiva Ferreira, Adalgisa de Sousa
Total Authors: 10
|
| Document type: | Journal article |
| Source: | Journal of Medical Virology; v. 89, n. 3, p. 458-462, MAR 2017. |
| Web of Science Citations: | 2 |
| Abstract | |
Mutations in the a determinant of S gene may develop co-existence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) in the serum of infected hepatitis B virus (HBV) individuals. Mutations in this region may change the antigenicity of HBsAg, which in turn, lead to escape of neutralizing action of anti-HBs antibodies. This study identified individuals with concomitant HBsAg and anti-HBs serological markers in individuals of Maranhao, Northeastern Brazil. Samples from a population-based study were evaluated for HBsAg, anti-HBs, and anti-HBc, and those that tested positive for simultaneous HBsAg and anti-HBs were submitted to HBV DNA quantification and S gene characterization by Sanger sequencing. Mutations were investigated in the a determinant located in major hydrophilic region (MHR) of the S gene. Among 3,984 samples analyzed, 92 (2.3%) were positive for HBsAg and three had the atypical HBsAg and anti-HBs-positive profile (3.26%). The frequency of HBsAg and anti-HBs co-existence was similar to previous studies. Only one individual harbored mutation in the S gene a determinant associated with this profile. Little is known about this phenomenon; however, studies as ours may contribute for future enlightenment of this important issue. (C) 2016 Wiley Periodicals, Inc. (AU) | |
| FAPESP's process: | 09/53946-3 - Acquisition of a genetic analyzer for automated DNA sequencing |
| Grantee: | João Renato Rebello Pinho |
| Support Opportunities: | Multi-user Equipment Program |