Natural products as mediators of disease

Autor(es)

Garg, Neha ; Luzzatto-Knaan, Tal ; Melnik, Alexey V. ; Caraballo-Rodriguez, Andres Mauricio ; Floros, Dimitrios J. ; Petras, Daniel ; Gregor, Rachel ; Dorrestein, Pieter C. ; Phelan, Vanessa V.

• Tipo de documento: Artigo de Revisão
• Fonte: NATURAL PRODUCT REPORTS; v. 34, n. 2, p. 194-219, FEB 1 2017.
• Citações Web of Science: 22

Resumo

Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe- derived natural products as mediators of human disease. (AU)

• Processo FAPESP: 12/21803-1 - Eliciação da biossíntese de produtos naturais a partir da interação de micro-organismos endofíticos
• Beneficiário: Andrés Mauricio Caraballo Rodríguez
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/01651-8 - Eliciação da biossíntese de produtos naturais a partir da interação de micro-organismos endofíticos
• Beneficiário: Andrés Mauricio Caraballo Rodríguez
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado