Skeletal muscle aging: influence of oxidative stress and physical exercise

Autor(es)

Gomes, Mariana Janini ; Martinez, Paula Felippe ; Pagan, Luana Urbano ; Damatto, Ricardo Luiz ; Mariano Cezar, Marcelo Diacardia ; Ruiz Lima, Aline Regina ; Okoshi, Katashi ; Okoshi, Marina Politi

• Tipo de documento: Artigo de Revisão
• Fonte: ONCOTARGET; v. 8, n. 12, p. 20428-20440, 2017.
• Citações Web of Science: 38

Resumo

Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencies are involved in the physiopathology of muscle changes. Sarcopenia is characterized by structural, biochemical, molecular and functional muscle changes. An imbalance between anabolic and catabolic intracellular signaling pathways and an increase in oxidative stress both play important roles in muscle abnormalities. Currently, despite the discovery of new targets and development of new drugs, nonpharmacological therapies such as physical exercise and nutritional support are considered the basis for prevention and treatment of age-associated muscle abnormalities. There has been an increase in information on signaling pathways beneficially modulated by exercise; nonetheless, studies are needed to establish the best type, intensity, and frequency of exercise to prevent or treat age-induced skeletal muscle alterations. (AU)

• Processo FAPESP: 14/23592-3 - Influência do exercício físico, aeróbio ou resistido, sobre a musculatura esquelética de ratos com infarto do miocárdio
• Beneficiário: Mariana Janini Gomes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/17539-5 - Influência do exercício físico no remodelamento cardíaco, estresse oxidativo e vias de sinalização das MAPK e do NF-kB de ratos espontaneamente hipertensos
• Beneficiário: Katashi Okoshi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/21972-3 - Influência do exercício físico sobre o estresse oxidativo, as MAPK e o NF-kB no músculo sóleo de ratos com insuficiência cardíaca induzida por estenose aórtica
• Beneficiário: Marina Politi Okoshi
• Modalidade de apoio: Auxílio à Pesquisa - Regular