| Full text | |
| Author(s): |
Gomes, Mariana Janini
;
Martinez, Paula Felippe
;
Pagan, Luana Urbano
;
Damatto, Ricardo Luiz
;
Mariano Cezar, Marcelo Diacardia
;
Ruiz Lima, Aline Regina
;
Okoshi, Katashi
;
Okoshi, Marina Politi
Total Authors: 8
|
| Document type: | Review article |
| Source: | ONCOTARGET; v. 8, n. 12, p. 20428-20440, 2017. |
| Web of Science Citations: | 37 |
| Abstract | |
Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencies are involved in the physiopathology of muscle changes. Sarcopenia is characterized by structural, biochemical, molecular and functional muscle changes. An imbalance between anabolic and catabolic intracellular signaling pathways and an increase in oxidative stress both play important roles in muscle abnormalities. Currently, despite the discovery of new targets and development of new drugs, nonpharmacological therapies such as physical exercise and nutritional support are considered the basis for prevention and treatment of age-associated muscle abnormalities. There has been an increase in information on signaling pathways beneficially modulated by exercise; nonetheless, studies are needed to establish the best type, intensity, and frequency of exercise to prevent or treat age-induced skeletal muscle alterations. (AU) | |
| FAPESP's process: | 15/17539-5 - Influence of physical exercise on cardiac remodeling, oxidative stress, and signaling of MAPK and NF-kB in spontaneously hypertensive rats |
| Grantee: | Katashi Okoshi |
| Support type: | Regular Research Grants |
| FAPESP's process: | 14/23592-3 - Influence of aerobic or resistance physical exercise on skeletal muscle of rats with myocardial infarction |
| Grantee: | Mariana Janini Gomes |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/21972-3 - Influence of physical exercise on oxidative stress and protein expression of MAPK and NF-kB pathways in soleus muscle of rats with aortic stenosis-induced heart failure |
| Grantee: | Marina Politi Okoshi |
| Support type: | Regular Research Grants |