| Texto completo | |
| Autor(es): |
Valente, Guilherme T.
;
Nakajima, Rafael T.
;
Fantinatti, Bruno E. A.
;
Marques, Diego F.
;
Almeida, Rodrigo O.
;
Simoes, Rafael P.
;
Martins, Cesar
Número total de Autores: 7
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | CHROMOSOMA; v. 126, n. 1, p. 73-81, FEB 2017. |
| Citações Web of Science: | 21 |
| Resumo | |
Though hundreds to thousands of reports have described the distribution of B chromosomes among diverse eukaryote groups, a comprehensive theory of their biological role has not yet clearly emerged. B chromosomes are classically understood as a sea of repetitive DNA sequences that are poor in genes and are maintained by a parasitic-drive mechanism during cell division. Recent developments in high-throughput DNA/RNA analyses have increased the resolution of B chromosome biology beyond those of classical and molecular cytogenetic methods; B chromosomes contain many transcriptionally active sequences, including genes, and can modulate the activity of autosomal genes. Furthermore, the most recent knowledge obtained from omics analyses, which is associated with a systemic view, has demonstrated that B chromosomes can influence cell biology in a complex way, possibly favoring their own maintenance and perpetuation. (AU) | |
| Processo FAPESP: | 13/04533-3 - Análise funcional de cromossomos B, utilizando o peixe ciclídeo Astatotilapia latifasciata como modelo |
| Beneficiário: | César Martins |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |