| Full text | |
| Author(s): |
Valente, Guilherme T.
;
Nakajima, Rafael T.
;
Fantinatti, Bruno E. A.
;
Marques, Diego F.
;
Almeida, Rodrigo O.
;
Simoes, Rafael P.
;
Martins, Cesar
Total Authors: 7
|
| Document type: | Review article |
| Source: | CHROMOSOMA; v. 126, n. 1, p. 73-81, FEB 2017. |
| Web of Science Citations: | 21 |
| Abstract | |
Though hundreds to thousands of reports have described the distribution of B chromosomes among diverse eukaryote groups, a comprehensive theory of their biological role has not yet clearly emerged. B chromosomes are classically understood as a sea of repetitive DNA sequences that are poor in genes and are maintained by a parasitic-drive mechanism during cell division. Recent developments in high-throughput DNA/RNA analyses have increased the resolution of B chromosome biology beyond those of classical and molecular cytogenetic methods; B chromosomes contain many transcriptionally active sequences, including genes, and can modulate the activity of autosomal genes. Furthermore, the most recent knowledge obtained from omics analyses, which is associated with a systemic view, has demonstrated that B chromosomes can influence cell biology in a complex way, possibly favoring their own maintenance and perpetuation. (AU) | |
| FAPESP's process: | 13/04533-3 - Functional analysis of B chromosomes: the cichlid fish Astatotilapia latifasciata as model |
| Grantee: | César Martins |
| Support Opportunities: | Regular Research Grants |