| Texto completo | |
| Autor(es): |
Batatinha, Helena A. P.
;
Lima, Edson A.
;
Teixeira, Alexandre A. S.
;
Souza, Camila O.
;
Biondo, Luana A.
;
Silveira, Loreana S.
;
Lira, Fabio S.
;
Rosa Neto, Jose C.
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Cellular Physiology; v. 232, n. 5, p. 1008-1019, MAY 2017. |
| Citações Web of Science: | 9 |
| Resumo | |
Nonalcoholic fatty liver disease (NAFLD) is one of the main liver diseases today, and may progress to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Some studies have shown the beneficial effects of aerobic exercise on reversing NAFLD. To verify whether chronic aerobic exercise improves the insulin resistance, liver inflammation, and steatohepatitis caused by a high fat diet (HF) and whether PPAR alpha is involved in these actions. C57BL6 wild type (WT) and PPAR-alpha knockout (KO) mice were fed with a standard diet (SD) or HF during 12 weeks; the HF mice were trained on a treadmill during the last 8 weeks. Serum glucose and insulin tolerances, serum levels of aspartate aminotransferase, hepatic content of triacylglycerol, cytokines, gene expression, and protein expression were evaluated in all animals. Chronic exposure to HF diet increased triacylglycerol accumulation in the liver, leading to NAFLD, increased aminotransferase in the serum, increased peripheral insulin resistance, and higher adiposity index. Exercise reduced all these parameters in both animal genotypes. The liver lipid accumulation was not associated with inflammation; trained KO mice, however, presented a huge inflammatory response that was probably caused by a decrease in PPAR-gamma expression. We conclude that exercise improved the damage caused by a HF independently of PPAR alpha, apparently by a peripheral fatty acid oxidation in the skeletal muscle. We also found that the absence of PPAR alpha together with exercise leads to a decrease in PPAR-gamma and a huge inflammatory response. (C) 2016 Wiley Periodicals, Inc. (AU) | |
| Processo FAPESP: | 13/25310-2 - Avaliação da resposta imuno-metabólica em células sanguíneas em indivíduos obesos: papel do exercício físico e do PPAR-gama |
| Beneficiário: | Fábio Santos de Lira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/09367-4 - Efeitos metabólicos da doxorrubicina no músculo esquelético e tecido adiposo. Possível papel adjuvante do treinamento físico e metformina. |
| Beneficiário: | José Cesar Rosa Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/01246-6 - Avaliação da resposta imuno-metabólica em macrófagos peritoneais de camundongos obesos: papel do exercício físico e do PPAR-gamma |
| Beneficiário: | Loreana Sanches Silveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |