Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients

Autor(es)

Paglioni, Mariana de Pauli ; Silva, Wagner Gomes ; Pereira, Juliana ; Migliorati, Cesar Augusto ; Lopes, Marcio Ajudarte ; de Almeida, Oslei Paes ; Goes, Mario Fernando ; Prado Ribeiro, Ana Carolina ; Brandao, Thais Bianca ; Santos-Silva, Alan Roger

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 123, n. 5, p. 591-599, MAY 2017.
• Citações Web of Science: 1

Resumo

Objective. To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. Study Design. Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin. Results. No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups. Conclusion. IV BP therapy does not thicken cementum or change the micromorphology of PDL. (AU)

• Processo FAPESP: 13/00429-7 - 2013 Annual Meeting (of The American Academy of Oral Medicine (AAOM)
• Beneficiário: Alan Roger dos Santos Silva
• Modalidade de apoio: Auxílio à Pesquisa - Reunião - Exterior
• Processo FAPESP: 12/06138-1 - Estudo prospectivo da incidência de trismo induzido por radioterapia em pacientes com carcinoma espinocelular de boca
• Beneficiário: Ana Carolina Prado Ribeiro e Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/18402-8 - Avaliação dos efeitos diretos da radiação sobre o esmalte, a dentina e a polpa dental de pacientes com câncer de cabeça e pescoço
• Beneficiário: Alan Roger dos Santos Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular