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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients

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Author(s):
Paglioni, Mariana de Pauli ; Silva, Wagner Gomes ; Pereira, Juliana ; Migliorati, Cesar Augusto ; Lopes, Marcio Ajudarte ; de Almeida, Oslei Paes ; Goes, Mario Fernando ; Prado Ribeiro, Ana Carolina ; Brandao, Thais Bianca ; Santos-Silva, Alan Roger
Total Authors: 10
Document type: Journal article
Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 123, n. 5, p. 591-599, MAY 2017.
Web of Science Citations: 1
Abstract

Objective. To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. Study Design. Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin. Results. No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups. Conclusion. IV BP therapy does not thicken cementum or change the micromorphology of PDL. (AU)

FAPESP's process: 12/06138-1 - A prospective study of radiation-induced trismus in patients with oral squamous cell carcinoma
Grantee:Ana Carolina Prado Ribeiro e Silva
Support type: Regular Research Grants
FAPESP's process: 13/18402-8 - Evaluation of the direct effects of radiation on the enamel, dentin and dental pulp of head and neck cancer patients
Grantee:Alan Roger dos Santos Silva
Support type: Regular Research Grants
FAPESP's process: 13/00429-7 - 2013 Annual Meeting (of The American Academy of Oral Medicine (AAOM)
Grantee:Alan Roger dos Santos Silva
Support type: Research Grants - Meeting - Abroad