| Texto completo | |
| Autor(es): |
Alvarado Huayhuaz, Jesus Antonio
;
Vitorino, Hector Aguilar
;
Campos, Othon Souto
;
Pires Serrano, Silvia Helena
;
Kaneko, Telma Mary
;
Esposito, Breno Pannia
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY; v. 41, p. 16-22, 2017. |
| Citações Web of Science: | 2 |
| Resumo | |
Iron acquisition by bacteria and fungi involves in several cases the promiscuous usage of siderophores. Thus, antibiotic resistance from these microorganisms can be circumvented through a strategy of loading toxic metals into siderophores (Trojan Horse Effect). Desferrioxamine (dfo) and its cell-permeant derivative desferrioxamine-caffeine (dfcaf) were complexed with aluminum or gallium for this purpose. The complexes Me(dfo) and Me(dfcaf) (Me = Al3+ and Ga3+) were synthesized and characterized by mass spectroscopy and cyclic voltammetry. Their relative stabilities were studied through competitive equilibria with fluorescent probes calcein, fluorescein-desferrioxamine and 8-hydroxyquinoline. Me(dfo) and Me(dfcaf) were consistently more toxic than free Me3+ against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans, demonstrating the Trojan Horse Effect. Wide spectrum antimicrobial action can be obtained by loading non-essential or toxic metal ions to microbes via a convenient siderophore carrier. (C) 2017 Elsevier GmbH. All rights reserved. (AU) | |
| Processo FAPESP: | 16/03709-9 - Modulação dos níveis e da reatividade do ferro fisiológico por novos quelantes naturais ou bifuncionais: possíveis aplicações na saúde humana |
| Beneficiário: | Breno Pannia Esposito |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/50318-1 - Desenvolvimento de compostos com interesse farmacológico ou medicinal e de sistemas para seu transporte, detecção e reconhecimento no meio biológico |
| Beneficiário: | Ana Maria da Costa Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |