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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Oral beta-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats

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Autor(es):
Caminhotto, Rennan de Oliveira ; Medeiros Komino, Ayumi Cristina ; Silva, Flaviane de Fatima ; Andreotti, Sandra ; Laurato Sertie, Rogerio Antonio ; Reis, Gabriela Boltes ; Lima, Fabio Bessa
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: NUTRITION & METABOLISM; v. 14, APR 24 2017.
Citações Web of Science: 6
Resumo

Background: Ketosis can be induced in humans and in animals by fasting or dietary interventions, such as ketogenic diets. However, the increasing interest on the ketogenic state has motivated the development of alternative approaches to rapidly increase ketonemia using less drastic interventions. Here, it was tested whether oral intake of a beta-hydroxybutyrate (beta HB) mineral salt mixture could increase ketonemia in Wistar rats without any other dietary changes, thereby being a useful model to study ketones effects alone on metabolism. Methods: beta HB salts were orally administered to provoke elevation in the ketonemia. Effects of this intervention were tested acutely (by gavage) and chronically (4 weeks in drinking water). Acutely, a concomitant glucose overload was used to suppress endogenous ketogenesis and verify whether beta HB salts were really absorbed or not. Long-term administration allowed to weekly evaluate the impact on ketonemia, blood glucose and, after 4 weeks, on body weight, visceral fat mass, lipid blood profile, serum lipolysis products and adiponectinemia. Results: beta HB salts increased ketonemia in acute and long-term administrations, improved blood lipid profile by raising HDL-cholesterol concentration and decreasing LDL/HDL ratio, while reduced visceral adipocyte volume. Mean ketonemia correlated positively with HDLc and negatively with adipocyte volume and serum lipolysis products. Conclusions: Oral beta HB can rapidly increase ketonemia and, therefore, be used as an acute and long-term animal model of ketosis. Long-term treatment points to important beneficial effects of ketone bodies in serum lipid concentrations and visceral fat mass. These results may help to explain the metabolic adaptations following ketogenic diets, such as a better body fat control and a serum lipid profile improvement. (AU)

Processo FAPESP: 14/10705-4 - Efeito do beta-hidroxibutirato na função mitocondrial de adipócitos brancos isolados
Beneficiário:Rennan de Oliveira Caminhotto
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/10218-1 - Caracterização dos efeitos da suplementação de sais de beta-hidroxibutirato em parâmetros plasmáticos, morfologia do tecido adiposo e expressão de adiponectina
Beneficiário:Ayumi Cristina Medeiros Komino
Linha de fomento: Bolsas no Brasil - Iniciação Científica