Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe

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Hawkins, Virginia E. ; Takakura, Ana C. ; Trinh, Ashley ; Malheiros-Lima, Milene R. ; Cleary, Colin M. ; Wenker, Ian C. ; Dubreuil, Todd ; Rodriguez, Elliot M. ; Nelson, Mark T. ; Moreira, Thiago S. ; Mulkey, Daniel K.

• Tipo de documento: Artigo Científico
• Fonte: eLIFE; v. 6, APR 7 2017.
• Citações Web of Science: 14

Resumo

Cerebral blood flow is highly sensitive to changes in CO2/H+ where an increase in CO2/H+ causes vasodilation and increased blood flow. Tissue CO2/H+ also functions as the main stimulus for breathing by activating chemosensitive neurons that control respiratory output. Considering that CO2/H+-induced vasodilation would accelerate removal of CO2/H+ and potentially counteract the drive to breathe, we hypothesize that chemosensitive brain regions have adapted a means of preventing vascular CO2/H+-reactivity. Here, we show in rat that purinergic signaling, possibly through P2Y(2/4) receptors, in the retrotrapezoid nucleus (RTN) maintains arteriole tone during high CO2/H+ and disruption of this mechanism decreases the CO(2)ventilatory response. Our discovery that CO2/H+-dependent regulation of vascular tone in the RTN is the opposite to the rest of the cerebral vascular tree is novel and fundamentally important for understanding how regulation of vascular tone is tailored to support neural function and behavior, in this case the drive to breathe. (AU)

• Processo FAPESP: 15/23376-1 - Núcleo retrotrapezóide, quimiossensibilidade central e automaticidade respiratória
• Beneficiário: Thiago dos Santos Moreira
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/22069-0 - Melhora nos mecanismos de regulação do fluxo sanguíneo encefálico em animais espontaneamente hipertensos: participação do exercício físico
• Beneficiário: Thiago dos Santos Moreira
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/22406-1 - Alterações respiratórias anatomofuncionais observadas em um modelo experimental da Doença de Parkinson
• Beneficiário: Ana Carolina Thomaz Takakura
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/07698-6 - Envolvimento dos neurônios catecolaminérgicos do bulbo ventrolateral rostral no controle da atividade respiratória
• Beneficiário: Milene Rodrigues Malheiros Lima
• Linha de fomento: Bolsas no Brasil - Doutorado