| Texto completo | |
| Autor(es): |
Ruiz Roa, Silvia Liliana
;
Martinez, Edson Zangiacomi
;
Martins, Clarissa Silva
;
Antonini, Sonir Rauber
;
de Castro, Margaret
;
Moreira, Ayrton Custodio
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Endocrinology; v. 158, n. 5, p. 1339-1346, MAY 2017. |
| Citações Web of Science: | 5 |
| Resumo | |
The postnatal synchronization of the circadian variation of the adrenal clock genes in mammals remains unknown. We evaluated the postnatal ontogeny of daily variation of clock genes (Clock/Bmal1/Per1/ Per2/Per3/Cry1/Cry2/Ror alpha/Rev-Erb alpha) and steroidogenesis-related genes (Star and Mc2r) in rat adrenals and its relationship with the emergence of plasma corticosterone rhythm using cosinor analysis. Plasma corticosterone circadian rhythm was detected from postnatal day (P) 1, with morning acrophase, between zeitgeber time (ZT)0 and ZT2. From P14, there was a nocturnal acrophase of corticosterone at ZT20, which was associated with pups' eye opening. From P3 there was a circadian variation of the mRNA expression of Bmal1, Per2, Per3, and Cry1 genes with morning acrophase, whereas Rev-Erba had nocturnal acrophase. From P14, Bmal1, Per2, Per3, and Cry1 acrophases advanced by approximately 10 hours, as compared with early neonatal days, becoming vespertine-nocturnal. In all postnatal ages, Per2 and Cry1 circadian profiles were synchronized in phase with the circadian rhythm of plasma corticosterone, whereas Bmal1 was in antiphase. An adult-like Star circadian rhythm profile was observed only from P21. In conclusion, our original data demonstrated a progressive postnatal maturation of the circadian variation of the adrenal clock genes in synchrony with the development of the corticosterone circadian rhythm in rats. (AU) | |
| Processo FAPESP: | 07/58365-3 - Fisiopatologia e etiopatogenia molecular de doenças relacionadas aos eixos corticotrófico, somatotrófico e neurohipofisário |
| Beneficiário: | Margaret de Castro |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 12/22164-2 - Ontogenia do ritmo circadiano do eixo Hipotálamo-Hipófise-Adrenal em ratos da linhagem Wistar: comparação da expressão dos genes do sistema "Clock" e do ritmo circadiano da corticosterona. |
| Beneficiário: | Silvia Liliana Ruiz Roa |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 13/09799-1 - Regulação da homeostase energética e do balanço hidromineral: das células aos sistemas fisiológicos |
| Beneficiário: | José Antunes Rodrigues |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |