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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Postnatal Ontogeny of the Circadian Expression of the Adrenal Clock Genes and Corticosterone Rhythm in Male Rats

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Author(s):
Ruiz Roa, Silvia Liliana ; Martinez, Edson Zangiacomi ; Martins, Clarissa Silva ; Antonini, Sonir Rauber ; de Castro, Margaret ; Moreira, Ayrton Custodio
Total Authors: 6
Document type: Journal article
Source: Endocrinology; v. 158, n. 5, p. 1339-1346, MAY 2017.
Web of Science Citations: 5
Abstract

The postnatal synchronization of the circadian variation of the adrenal clock genes in mammals remains unknown. We evaluated the postnatal ontogeny of daily variation of clock genes (Clock/Bmal1/Per1/ Per2/Per3/Cry1/Cry2/Ror alpha/Rev-Erb alpha) and steroidogenesis-related genes (Star and Mc2r) in rat adrenals and its relationship with the emergence of plasma corticosterone rhythm using cosinor analysis. Plasma corticosterone circadian rhythm was detected from postnatal day (P) 1, with morning acrophase, between zeitgeber time (ZT)0 and ZT2. From P14, there was a nocturnal acrophase of corticosterone at ZT20, which was associated with pups' eye opening. From P3 there was a circadian variation of the mRNA expression of Bmal1, Per2, Per3, and Cry1 genes with morning acrophase, whereas Rev-Erba had nocturnal acrophase. From P14, Bmal1, Per2, Per3, and Cry1 acrophases advanced by approximately 10 hours, as compared with early neonatal days, becoming vespertine-nocturnal. In all postnatal ages, Per2 and Cry1 circadian profiles were synchronized in phase with the circadian rhythm of plasma corticosterone, whereas Bmal1 was in antiphase. An adult-like Star circadian rhythm profile was observed only from P21. In conclusion, our original data demonstrated a progressive postnatal maturation of the circadian variation of the adrenal clock genes in synchrony with the development of the corticosterone circadian rhythm in rats. (AU)

FAPESP's process: 12/22164-2 - Ontogeny of the circadian rhythm of the Hypothalamic-Pituitary-Adrenal in Wistar rats: comparison of gene expression of "Clock" system and the circadian rhythm of corticosterone.
Grantee:Silvia Liliana Ruiz Roa
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/09799-1 - Energy balance and body fluid homeostasis control: from cells to the physiological systems
Grantee:José Antunes Rodrigues
Support Opportunities: Research Projects - Thematic Grants