| Texto completo | |
| Autor(es): Mostrar menos - |
Almeida, Sandro S.
;
Corgosinho, Flavia C.
;
Amorim, Carlos E. N.
;
Gregnani, Marcos F.
;
Campos, Raquel M. S.
;
Masquio, Deborah C. L.
;
Sanches, Priscila L.
;
Ganen, Aline P.
;
Pesquero, Joao B.
;
Damaso, Ana R.
;
Mello, Marco T.
;
Tufik, Sergio
;
Araujo, Ronaldo C.
Número total de Autores: 13
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM; v. 18, n. 2 APR-JUN 2017. |
| Citações Web of Science: | 1 |
| Resumo | |
Introduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes. Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response. Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy. (AU) | |
| Processo FAPESP: | 11/50356-0 - Análise de complemento protéico plasmático e de fatores de risco metabólicos em adolescentes obesos em tratamento no Centro de Recuperação e Educação Nutricional (CREN) |
| Beneficiário: | Ana Raimunda Dâmaso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/20082-7 - Sistema calicreína cininas no exercício físico e metabolismo |
| Beneficiário: | Ronaldo de Carvalho Araújo |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 11/50414-0 - Influência da hiperleptinemia nas respostas inflamatórias e aterogênicas em adolescentes obesos |
| Beneficiário: | Ana Raimunda Dâmaso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |