| Full text | |
| Author(s): Show less - |
Almeida, Sandro S.
;
Corgosinho, Flavia C.
;
Amorim, Carlos E. N.
;
Gregnani, Marcos F.
;
Campos, Raquel M. S.
;
Masquio, Deborah C. L.
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Sanches, Priscila L.
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Ganen, Aline P.
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Pesquero, Joao B.
;
Damaso, Ana R.
;
Mello, Marco T.
;
Tufik, Sergio
;
Araujo, Ronaldo C.
Total Authors: 13
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| Document type: | Journal article |
| Source: | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM; v. 18, n. 2 APR-JUN 2017. |
| Web of Science Citations: | 1 |
| Abstract | |
Introduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes. Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response. Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy. (AU) | |
| FAPESP's process: | 15/20082-7 - Kallikrein kinin system in physical exercise and metabolism |
| Grantee: | Ronaldo de Carvalho Araújo |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents |
| Grantee: | Ana Raimunda Dâmaso |
| Support Opportunities: | Regular Research Grants |