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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Metabolic Impact of Light Phase-Restricted Fructose Consumption Is Linked to Changes in Hypothalamic AMPK Phosphorylation and Melatonin Production in Rats

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Autor(es):
Faria, Juliana de Almeida ; de Araujo, Thiago Matos F. ; Razolli, Daniela S. ; Ignacio-Souza, Leticia Martins ; Souza, Dailson Nogueira ; Bordin, Silvana ; Anhe, Gabriel Forato
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: NUTRIENTS; v. 9, n. 4 APR 2017.
Citações Web of Science: 2
Resumo

Recent studies show that the metabolic effects of fructose may vary depending on the phase of its consumption along with the light/dark cycle. Here, we investigated the metabolic outcomes of fructose consumption by rats during either the light (LPF) or the dark (DPF) phases of the light/dark cycle. This experimental approach was combined with other interventions, including restriction of chow availability to the dark phase, melatonin administration or intracerebroventricular inhibition of adenosine monophosphate-activated protein kinase (AMPK) with Compound C. LPF, but not DPF rats, exhibited increased hypothalamic AMPK phosphorylation, glucose intolerance, reduced urinary 6-sulfatoxymelatonin (6-S-Mel) (a metabolite of melatonin) and increased corticosterone levels. LPF, but not DPF rats, also exhibited increased chow ingestion during the light phase. The mentioned changes were blunted by Compound C. LPF rats subjected to dark phase-restricted feeding still exhibited increased hypothalamic AMPK phosphorylation but failed to develop the endocrine and metabolic changes. Moreover, melatonin administration to LPF rats reduced corticosterone and prevented glucose intolerance. Altogether, the present data suggests that consumption of fructose during the light phase results in out-of-phase feeding due to increased hypothalamic AMPK phosphorylation. This shift in spontaneous chow ingestion is responsible for the reduction of 6-S-Mel and glucose intolerance. (AU)

Processo FAPESP: 12/11409-4 - Relação entre horário da ingestão de frutose e ritmo de atividade AMPK no hipotálamo: possíveis interações entre efeitos metabólicos e produção de melatonina
Beneficiário:Juliana de Almeida Faria
Linha de fomento: Bolsas no Brasil - Doutorado