Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism

Autor(es)

Pereira, Rodrigo Martins ; Botezelli, Jose Diego ; da Cruz Rodrigues, Kellen Cristina ; Mekary, Rania A. ; Cintra, Dennys Esper ; Pauli, Jose Rodrigo ; Ramos da Silva, Adelino Sanchez ; Ropelle, Eduardo Rochete ; de Moura, Leandro Pereira

• Tipo de documento: Artigo de Revisão
• Fonte: NUTRIENTS; v. 9, n. 4 APR 2017.
• Citações Web of Science: 17

Resumo

Fructose consumption has been growing exponentially and, concomitant with this, the increase in the incidence of obesity and associated complications has followed the same behavior. Studies indicate that fructose may be a carbohydrate with greater obesogenic potential than other sugars. In this context, the liver seems to be a key organ for understanding the deleterious health effects promoted by fructose consumption. Fructose promotes complications in glucose metabolism, accumulation of triacylglycerol in the hepatocytes, and alterations in the lipid profile, which, associated with an inflammatory response and alterations in the redox state, will imply a systemic picture of insulin resistance. However, physical exercise has been indicated for the treatment of several chronic diseases. In this review, we show how each exercise protocol (aerobic, strength, or a combination of both) promote improvements in the obesogenic state created by fructose consumption as an improvement in the serum and liver lipid profile (high-density lipoprotein (HDL) increase and decrease triglyceride (TG) and low-density lipoprotein (LDL) levels) and a reduction of markers of inflammation caused by an excess of fructose. Therefore, it is concluded that the practice of aerobic physical exercise, strength training, or a combination of both is essential for attenuating the complications developed by the consumption of fructose. (AU)

• Processo FAPESP: 15/07199-2 - Papel da clusterina/ApoJ na sinalização da insulina em resposta ao exercício físico em roedores e em humanos
• Beneficiário: Leandro Pereira de Moura
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/12569-6 - Efeitos de diferentes intensidades do exercício físico no metabolismo da clusterina e sua interferência na sinalização da insulina em roedores
• Beneficiário: Rodrigo Martins Pereira
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto