Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism

Author(s)

Pereira, Rodrigo Martins ; Botezelli, Jose Diego ; da Cruz Rodrigues, Kellen Cristina ; Mekary, Rania A. ; Cintra, Dennys Esper ; Pauli, Jose Rodrigo ; Ramos da Silva, Adelino Sanchez ; Ropelle, Eduardo Rochete ; de Moura, Leandro Pereira

• Document type: Review article
• Source: NUTRIENTS; v. 9, n. 4 APR 2017.
• Web of Science Citations: 17

Abstract

Fructose consumption has been growing exponentially and, concomitant with this, the increase in the incidence of obesity and associated complications has followed the same behavior. Studies indicate that fructose may be a carbohydrate with greater obesogenic potential than other sugars. In this context, the liver seems to be a key organ for understanding the deleterious health effects promoted by fructose consumption. Fructose promotes complications in glucose metabolism, accumulation of triacylglycerol in the hepatocytes, and alterations in the lipid profile, which, associated with an inflammatory response and alterations in the redox state, will imply a systemic picture of insulin resistance. However, physical exercise has been indicated for the treatment of several chronic diseases. In this review, we show how each exercise protocol (aerobic, strength, or a combination of both) promote improvements in the obesogenic state created by fructose consumption as an improvement in the serum and liver lipid profile (high-density lipoprotein (HDL) increase and decrease triglyceride (TG) and low-density lipoprotein (LDL) levels) and a reduction of markers of inflammation caused by an excess of fructose. Therefore, it is concluded that the practice of aerobic physical exercise, strength training, or a combination of both is essential for attenuating the complications developed by the consumption of fructose. (AU)

• FAPESP's process: 15/07199-2 - Role of clusterin/ApoJ on insulin signalling in response to physical exercise in rodents and humans
• Grantee: Leandro Pereira de Moura
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/12569-6 - Effects of different exercise intensities on clusterin metabolism and its interference on insulin signaling in rodents
• Grantee: Rodrigo Martins Pereira
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)