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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Ruthenium(II)/triphenylphosphine complexes: An effective way to improve the cytotoxicity Of lapachol

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Autor(es):
Oliveira, Katia M. ; Correa, Rodrigo S. ; Barbosa, Marilia I. F. ; Ellena, Javier ; Cominetti, Marcia R. ; Batista, Alzir A.
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: Polyhedron; v. 130, p. 108-114, JUL 7 2017.
Citações Web of Science: 11
Resumo

This study reports on the synthesis of a new ruthenium(II) complex, cis-{[}Ru(PPh3)(2)(lap)(2)] (1) with two molecules of the natural product known as lapachol {[}lap = (2-hydroxy-3-(3-methyl-2-buthenyl)-1,4-naphthoquinone)] coordinated as bidentated by oxygen atoms and two monodentate PPh3 (triphenylphosphine) in a cis configuration. This neutral complex was characterized by spectroscopic analysis, single-crystal X-ray diffraction, elemental analysis, molar conductivity and cyclic voltammetry. In this study, ruthenium complex trans-{[}Ru(lap)(PPh3)(2)(phen)]PF6 (2) was used for comparison purposes. The interaction of ruthenium complexes (1) and (2) with CT-DNA was evaluated by UV-Vis and circular dichroism and it was observed that the complexes interact weakly with the CT-DNA. The fluorescence measurements suggest that complex (1) shows stronger interaction with HSA and BSA proteins compared to complex (2). Cytotoxicity assays against A549 (lung cancer), MDA-MB-231 (breast cancer) and V79 (non-tumoral lung) revealed that complex (2) is more active (lower IC50 values) than complex (1) and the cisplatin, used as a reference. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 14/04147-9 - Avaliação das propriedades anticâncer de complexos de rutênio(II) contendo os bioligantes lapachol e lausona
Beneficiário:Katia Mara de Oliveira
Linha de fomento: Bolsas no Brasil - Doutorado