Ruthenium(II)/triphenylphosphine complexes: An effective way to improve the cytotoxicity Of lapachol

Author(s)

Oliveira, Katia M. ; Correa, Rodrigo S. ; Barbosa, Marilia I. F. ; Ellena, Javier ; Cominetti, Marcia R. ; Batista, Alzir A.

• Document type: Journal article
• Source: Polyhedron; v. 130, p. 108-114, JUL 7 2017.
• Web of Science Citations: 12

Abstract

This study reports on the synthesis of a new ruthenium(II) complex, cis-{[}Ru(PPh3)(2)(lap)(2)] (1) with two molecules of the natural product known as lapachol {[}lap = (2-hydroxy-3-(3-methyl-2-buthenyl)-1,4-naphthoquinone)] coordinated as bidentated by oxygen atoms and two monodentate PPh3 (triphenylphosphine) in a cis configuration. This neutral complex was characterized by spectroscopic analysis, single-crystal X-ray diffraction, elemental analysis, molar conductivity and cyclic voltammetry. In this study, ruthenium complex trans-{[}Ru(lap)(PPh3)(2)(phen)]PF6 (2) was used for comparison purposes. The interaction of ruthenium complexes (1) and (2) with CT-DNA was evaluated by UV-Vis and circular dichroism and it was observed that the complexes interact weakly with the CT-DNA. The fluorescence measurements suggest that complex (1) shows stronger interaction with HSA and BSA proteins compared to complex (2). Cytotoxicity assays against A549 (lung cancer), MDA-MB-231 (breast cancer) and V79 (non-tumoral lung) revealed that complex (2) is more active (lower IC50 values) than complex (1) and the cisplatin, used as a reference. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 14/04147-9 - Evaluation of anticancer properties of ruthenium(II)complexes containing lapachol and lawsone bioligands
• Grantee: Katia Mara de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate