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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The degree of cardiac baroreflex involvement during active standing is associated with the quality of life in fibromyalgia patients

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Autor(es):
Zamuner, Antonio Roberto ; Porta, Alberto ; Andrade, Carolina Pieroni ; Forti, Meire ; Marchi, Andrea ; Furlan, Raffaello ; Barbic, Franca ; Catai, Aparecida Maria ; Silva, Ester
Número total de Autores: 9
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 12, n. 6 JUN 14 2017.
Citações Web of Science: 1
Resumo

Fibromyalgia syndrome (FMS) is a rheumatologic disorder characterized by chronic widespread pain, fatigue and other symptoms. Baroreflex dysfunction has been observed in women with FMS. However, it is unknown whether the limited involvement of the baroreflex control during an orthostatic stimulus has some impact on the quality of life of the FMS patient. Therefore, the aim of the study is evaluate the relationship between the quality of life of the FMS patient and indexes of the cardiovascular autonomic control as estimated from spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP). We enrolled 35 women with FMS (age: 48.8 +/- 8.9 years; body mass index: 29.3 +/- 4.3 Kg/m(2)). The electrocardiogram, non-invasive finger blood pressure and respiratory activity were continuously recorded during 15 minutes at rest in supine position (REST) and in orthostatic position during active standing (STAND). Traditional cardiovascular autonomic control markers were assessed along with a Granger causality index assessing the strength of the causal relation from SAP to HP (CRSAP -> HP) and measuring the degree of involvement of the cardiac baroreflex. The impact of FMS on quality of life was quantified by the fibromyalgia impact questionnaire (FIQ) and visual analog score for pain (VAS pain). No significant linear association was found between FIQ scores and the traditional cardiovascular indexes both at REST and during STAND (p > 0.05). However, a negative relationship between CRSAP -> HP during STAND and FIQ score was found (r = -0.56, p < 0.01). Similar results were found with VAS pain. In conclusion, the lower the degree of cardiac baroreflex involvement during STAND in women with FMS, the higher the impact of FMS on the quality of life, thus suggesting that Granger causality analysis might be clinically helpful in assessing the state of the FMS patient. (AU)

Processo FAPESP: 15/08445-7 - Função barorreflexa simpática e cardíaca em pacientes com síndrome fibromiálgica
Beneficiário:Antonio Roberto Zamunér
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 11/22122-5 - Estudo das adaptações biomecânicas, sensoriais, cardiorespiratórias e da qualidade de vida associadas à intervenção fisioterapêutica na síndrome fibromiálgica
Beneficiário:Tania de Fatima Salvini
Linha de fomento: Auxílio à Pesquisa - Temático