Significant differe nces in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients

Autor(es)

Raquel Ajub Moyses ^[1] ; Rossana Verónica Mendoza López ^[2] ; Patrícia Maluf Cury ^[3] ; Sheila Aparecida Coelho Siqueira ^[4] ; Otávio Alberto Curioni ^[5] ; José Francisco de Gois Filho ^[6] ; David Livingstone Alves Figueiredo ; Eloiza Helena Tajara ^[8] ; Pedro Michaluart Jr

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Hospital das Clínicas. Faculdade de Medicina - Brasil

^[2] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia - Brasil

^[3] Faculdade de Medicina de São José do Rio Preto. Departamento de Patologia e Medicina Legal - Brasil

^[4] Universidade de São Paulo. Faculdade de Medicina - Brasil

^[5] Hospital Heliópolis. Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço - Brasil

^[6] Instituto do Câncer Arnaldo Vieira de Carvalho. Departamento de Cirurgia de Cabeça e Pescoço - Brasil

^[8] Faculdade de Medicina de São José do Rio Preto. Departamento de Biologia Molecular - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Clinics; v. 68, n. 6, p. 738-744, 2013-06-00.

Resumo

OBJECTIVE: As a lifestyle-related disease, social and cultural disparities may influence the features of squamous cell carcinoma of the head and neck in different geographic regions. We describe demographic, clinical, and pathological aspects of squamous cell carcinoma of the head and neck according to the smoking and alcohol consumption habits of patients in a Brazilian cohort. METHODS: We prospectively analyzed the smoking and alcohol consumption habits of 1,633 patients enrolled in five São Paulo hospitals that participated in the Brazilian Head and Neck Genome Project - Gencapo. RESULTS: The patients who smoked and drank were younger, and those who smoked were leaner than the other patients, regardless of alcohol consumption. The non-smokers/non-drinkers were typically elderly white females who had more differentiated oral cavity cancers and fewer first-degree relatives who smoked. The patients who drank presented significantly more frequent nodal metastasis, and those who smoked presented less-differentiated tumors. CONCLUSIONS: The patients with squamous cell carcinoma of the head and neck demonstrated demographic, clinical, and pathological features that were markedly different according to their smoking and drinking habits. A subset of elderly females who had oral cavity cancer and had never smoked or consumed alcohol was notable. Alcohol consumption seemed to be related to nodal metastasis, whereas smoking correlated with the degree of differentiation. (AU)

• Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático