Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture

Autor(es)

Severino, Patricia ; Ariga, Suely Kubo ; Barbeiro, Hermes Vieira ; de Lima, Thais Martins ; Silva, Elisangela de Paula ; Barbeiro, Denise Frediani ; Cesar Machado, Marcel Cerqueira ; Nizet, Victor ; da Silva, Fabiano Pinheiro

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MOLECULAR MEDICINE-JMM; v. 95, n. 9, p. 995-1003, SEP 2017.
• Citações Web of Science: 4

Resumo

Antimicrobial peptides possess a myriad of molecular properties including bacterial killing and the regulation of many aspects of innate immunity. Cathelicidins are a group of antimicrobial peptides widely investigated by the scientific community. Many studies have focused on the bactericidal and pro-inflammatory roles of cathelicidins. Because the role of endogenous cathelicidin expression remains obscure in deep-seated systemic infections, we induced sepsis in cathelicidin knockout and wild-type (WT) mice by cecal ligation and puncture, performing transcriptome screening by DNA micro-array in conjunction with other immunologic assays. Cathelicidin-deficient mice showed increased survival compared to WT mice in this established experimental model of polymicrobial sepsis, in association with upregulation of certain key inflammatory response genes. Therefore, cathelicidins can exert both pro- and anti-inflammatory activities depending on the disease and cellular context. (AU)

• Processo FAPESP: 15/00892-4 - Peptídeos antimicrobianos em sepse: uma abordagem sistêmica
• Beneficiário: Fabiano Pinheiro da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular