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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Metabolic syndrome and inflammation in adipose tissue occur at different times in animals submitted to a high-sugar/fat diet

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Autor(es):
Francisqueti, Fabiane Valentini ; Nascimento, Andre Ferreira ; Minatel, Igor Otavio ; Dias, Marcos Correa ; Melo Luvizotto, Renata de Azevedo ; Berchieri-Ronchi, Carolina ; Ferreira, Ana Lucia A. ; Correa, Camila Renata
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF NUTRITIONAL SCIENCE; v. 6, AUG 21 2017.
Citações Web of Science: 4
Resumo

Obesity is associated with low-grade inflammation, triggered in adipose tissue, which may occur due to an excess of SFA from the diet that can be recognised by Toll-like receptor-4. This condition is involved in the development of components of the metabolic syndrome associated with obesity, especially insulin resistance. The aim of the study was to evaluate the manifestation of the metabolic syndrome and adipose tissue inflammation as a function of the period of time in which rats were submitted to a high-sugar/fat diet (HSF). Male Wistar rats were divided into six groups to receive the control diet (C) or the HSF for 6, 12 or 24 weeks. HSF increased the adiposity index in all HSF groups compared with the C group. HSF was associated with higher plasma TAG, glucose, insulin and leptin levels. Homeostasis model assessment increased in HSF compared with C rats at 24 weeks. Both TNF- and IL-6 were elevated in the epididymal adipose tissue of HSF rats at 24 weeks compared with HSF at 6 weeks and C at 24 weeks. Only the HSF group at 24 weeks showed increased expression of both Toll-like receptor-4 and NF-B. More inflammatory cells were found in the HSF group at 24 weeks. We can conclude that the metabolic syndrome occurs independently of the inflammatory response in adipose tissue and that inflammation is associated with hypertrophy of adipocytes, which varies according to duration of exposure to the HSF. (AU)

Processo FAPESP: 11/14132-0 - Papel do TLR-4 na resposta inflamatória e resistência insulínica no tecido adiposo em uma condição crônica de sobrecarga nutricional
Beneficiário:Camila Renata Corrêa
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/14593-8 - Papel do TLR-4 na resposta inflamatória e resistência insulínica no tecido adiposo em condição de sobrecarga nutricional crônica
Beneficiário:Fabiane Valentini Francisqueti Ferron
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 15/10626-0 - Inter-relação do gama-orizanol e ativação dos receptores Adipo- R1 e Adipo- R2: possível efeito na melhora da função renal associada à obesidade
Beneficiário:Camila Renata Corrêa
Linha de fomento: Auxílio à Pesquisa - Regular