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Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases

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Autor(es):
Ciregia, Federica ; Urbani, Andrea ; Palmisano, Giuseppe
Número total de Autores: 3
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN MOLECULAR NEUROSCIENCE; v. 10, AUG 31 2017.
Citações Web of Science: 22
Resumo

Extracellular vesicles (EVs) can be classified into apoptotic bodies, microvesicles (MVs), and exosomes, based on their origin or size. Exosomes are the smallest and best characterized vesicles which derived from the endosomal system. These vesicles are released from many different cell types including neuronal cells and their functions in the nervous system are investigated. They have been proposed as novel means for intercellular communication, which takes part not only to the normal neuronal physiology but also to the transmission of pathogenic proteins. Indeed, exosomes are fundamental to assemble and transport proteins during development, but they can also transfer neurotoxic misfolded proteins in pathogenesis. The present review will focus on their roles in neurological diseases, specifically brain tumors, such as glioblastoma (GBM), neuroblastoma (NB), medulloblastoma (MB), and metastatic brain tumors and chronic neurodegenerative diseases, such as Alzheimer, Parkinson, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Huntington, and Prion diseseases highlighting their involvement in spreading neurotoxicity, in therapeutics, and in pathogenesis. (AU)

Processo FAPESP: 16/50356-4 - MYC: a regulator of exosome protein cargo?
Beneficiário:Giuseppe Palmisano
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/06863-3 - Modificações pós-traducionais para o diagnóstico de câncer e doenças parasitárias: abordagens metodológicas e implicações biológicas
Beneficiário:Giuseppe Palmisano
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores