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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chronic exercise reduces hypothalamic transforming growth factor-beta 1 in middle-aged obese mice

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Autor(es):
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Silva, Vagner R. R. ; Katashima, Carlos K. ; Lenhare, Luciene ; Silva, Carla G. B. ; Morari, Joseane ; Camargo, Rafael L. ; Velloso, Licio A. ; Saad, Mario A. ; da Silva, Adelino S. R. ; Pauli, Jose Rodrigo ; Ropelle, Eduardo Rochete
Número total de Autores: 11
Tipo de documento: Artigo Científico
Fonte: AGING-US; v. 9, n. 8, p. 1926-1940, AUG 2017.
Citações Web of Science: 4
Resumo

Obesity and aging are associated with hypothalamic inflammation, hyperphagia and abnormalities in the thermogenesis control. It has been demonstrated that the association between aging and obesity induces hypothalamic inflammation and metabolic disorders, at least in part, through the atypical hypothalamic transforming growth factor-beta (TGF-beta 1). Physical exercise has been used to modulate several metabolic parameters. Thus, the aim of this study was to evaluate the impact of chronic exercise on TGF-beta 1 expression in the hypothalamus of Middle-Aged mice submitted to a one year of high-fat diet (HFD) treatment. We observed that long-term of HFD-feeding induced hypothalamic TGF-beta 1 accumulation, potentiated the hypothalamic inflammation, body weight gain and defective thermogenesis of Middle-Aged mice when compared to Middle-Aged animals fed on chow diet. As expected, chronic exercise induced negative energy balance, reduced food consumption and increasing the energy expenditure, which promotes body weight loss. Interestingly, exercise training reduced the TGF-beta 1 expression and IkB-alpha ser32 phosphorylation in the hypothalamus of Middle-Aged obese mice. Taken together our study demonstrated that chronic exercise suppressed the TGF-beta 1/IkB-alpha axis in the hypothalamus and improved the energy homeostasis in an animal model of obesity-associated to aging. (AU)

Processo FAPESP: 16/01089-3 - Avaliação da UPRmt e do desequilíbrio mitonuclear em resposta ao treinamento físico: Uma abordagem multi-orgânica.
Beneficiário:Eduardo Rochete Ropelle
Linha de fomento: Auxílio à Pesquisa - Regular