High Dosage of Vitamin D Regulates the Energy Metabolism and Increases Insulin Sensitivity, but are Associated with High Levels of Kidney Damage

Autor(es):Mostrar menos -

Gaspar, Rafael Calais ; Botezelli, Jose Diego ; Kuga, Gabriel Keine ; Munoz, Vitor Rosetto ; Coope, Andressa ; Pereira, Rodrigo Martins ; Ramos da Silva, Adelino Sanchez ; Cintra, Dennys Esper ; de Moura, Leandro Pereira ; Ropelle, Eduardo Rochete ; Pauli, Jose Rodrigo

• Tipo de documento: Artigo Científico
• Fonte: Drug Development Research; v. 78, n. 5, p. 203-209, AUG 2017.
• Citações Web of Science: 3

Resumo

Metabolic disorders are responsible for more than 60% of all deaths worldwide. Calcitriol or vitamin D (vitD) deficiency is associated with a large proportion of these diseases is an important therapeutic target for exploration. This study evaluated the administration of high doses of vitD (3000 IU/kg) in obese and insulin-resistant C57BL/6J mice. Our results demonstrated that although high doses of vitD provided metabolic benefits such as increased insulin sensitivity and decreased body mass, this was associated with significant damage in the kidneys of obese mice. These findings support the role of vitD as a therapeutic strategy against metabolic disorders. However, caution is required with the dose administrated, and the renal damage associated still needs to be investigated. Drug Dev Res 78 : 203-209, 2017. (c) 2017 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 16/18488-8 - O papel do exercício físico nas vias moleculares de captação de glicose em camundongos nocautes para GLUT-4
• Beneficiário: José Rodrigo Pauli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/20293-2 - Efeitos do exercício de endurance e de força nas vias de captação de glicose em camundongos nocaute heterozigotos GLUT4
• Beneficiário: José Diego Botezelli
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado