Assessment of the Effect of Two Distinct Restricted Iodine Diet Durations on Urinary Iodine Levels (Collected over 24 h or as a Single-Spot Urinary Sample) and Na (+)/I- Symporter Expression

Autor(es)

Padovani, Rosalia P. ^{[1, 2, 3]} ; Maciel, Rui M. B. ^{[1, 2]} ; Kasamatsu, Teresa S. ^[2] ; Freitas, Beatriz C. G. ^[2] ; Marone, Marilia M. S. ^[3] ; Camacho, Cleber P. ^{[1, 2]} ; Biscolla, Rosa Paula M. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Inst Israelita Ensino & Pesquisa Albert Einstein, Thyroid Dis Ctr, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Escola Paulista Med, Thyroid Dis Ctr & Lab Mol & Translat Endocrinol, Dept Med, Div Endocrinol, Rua Pedro Toledo 669, 11th Floor, BR-04039033 Sao Paulo - Brazil

^[3] Irmandade Santa Casa Misericordia Sao Paulo, Dept Nucl Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN THYROID JOURNAL; v. 4, n. 2, p. 99-105, 2015.
• Citações Web of Science: 0

Resumo

Introduction: A restricted iodine diet (RID) may be recommended for depletion of the whole-body iodine pool in patients with differentiated thyroid cancer referred for radioiodine treatment or a whole-body scan. Evaluation of the iodine pool is possible through urinary iodide (UI) measurements, which can be collected in 24-hour (24U) or spot urinary (sU) samples. However, the minimum period required for an RID to lower the iodine pool, the measurement of iodine in sU samples as a iodine pool marker, and the influence of the iodine pool on Na (+)/I- symporter (NIS) expression are debatable in the literature. Objectives: To compare the effects of 15-and 30-day RID on UI measurements in 24U and sU samples and the impact of RID on NIS expression. Methods: Thyroidectomized patients went on a 15-or 30-day RID and collected 24U and sU samples before and after the RID. Twenty healthy individuals were evaluated for mRNA NIS expression before and after the RID. Results: Of 306 patients, only 125 properly complied with both the RID and 24U collection. We observed a correlation between sU and 24U UI before the RID (n = 306, rho = 0.47, p < 0.001), after a 15-day RID (n = 79, rho = 0.49, p < 0.001), and after a 30-day RID (n = 46, rho = 0.73, p < 0.001). There was a significant decrease in UI after the RID. The median UI measurement was 275 mu g/l at baseline and 99 and 80 mu g/l after a 15-and 30-day RID, respectively. There was a significant increase in NIS expression after a 15-day RID. Conclusions: A 15-day RID is sufficient to deplete the iodine pool. sU can replace 24U UI as a marker for assessing the iodine pool. NIS expression was increased after a 15-day RID. (C) 2015 European Thyroid Association Published by S. Karger AG, Basel (AU)

• Processo FAPESP: 09/50573-1 - Comparação da dosagem de iodo na urina de 24 horas e amostra isolada e sua correlação com a dieta restrita em iodo, exposição a contrastes iodados e expressão do transportador sódio/iodo
• Beneficiário: Rui Monteiro de Barros Maciel
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/50574-8 - Comparação da dosagem de iodo na urina de 24 horas e amostra isolada e sua correlação com a dieta restrita em iodo exposição a contrastes iodados e expressão do transportador sódio/iodo
• Beneficiário: Rosalia Do Prado Padovani
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto