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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Assessment of the Effect of Two Distinct Restricted Iodine Diet Durations on Urinary Iodine Levels (Collected over 24 h or as a Single-Spot Urinary Sample) and Na (+)/I- Symporter Expression

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Author(s):
Padovani, Rosalia P. [1, 2, 3] ; Maciel, Rui M. B. [1, 2] ; Kasamatsu, Teresa S. [2] ; Freitas, Beatriz C. G. [2] ; Marone, Marilia M. S. [3] ; Camacho, Cleber P. [1, 2] ; Biscolla, Rosa Paula M. [1, 2]
Total Authors: 7
Affiliation:
[1] Inst Israelita Ensino & Pesquisa Albert Einstein, Thyroid Dis Ctr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Thyroid Dis Ctr & Lab Mol & Translat Endocrinol, Dept Med, Div Endocrinol, Rua Pedro Toledo 669, 11th Floor, BR-04039033 Sao Paulo - Brazil
[3] Irmandade Santa Casa Misericordia Sao Paulo, Dept Nucl Med, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: EUROPEAN THYROID JOURNAL; v. 4, n. 2, p. 99-105, 2015.
Web of Science Citations: 0
Abstract

Introduction: A restricted iodine diet (RID) may be recommended for depletion of the whole-body iodine pool in patients with differentiated thyroid cancer referred for radioiodine treatment or a whole-body scan. Evaluation of the iodine pool is possible through urinary iodide (UI) measurements, which can be collected in 24-hour (24U) or spot urinary (sU) samples. However, the minimum period required for an RID to lower the iodine pool, the measurement of iodine in sU samples as a iodine pool marker, and the influence of the iodine pool on Na (+)/I- symporter (NIS) expression are debatable in the literature. Objectives: To compare the effects of 15-and 30-day RID on UI measurements in 24U and sU samples and the impact of RID on NIS expression. Methods: Thyroidectomized patients went on a 15-or 30-day RID and collected 24U and sU samples before and after the RID. Twenty healthy individuals were evaluated for mRNA NIS expression before and after the RID. Results: Of 306 patients, only 125 properly complied with both the RID and 24U collection. We observed a correlation between sU and 24U UI before the RID (n = 306, rho = 0.47, p < 0.001), after a 15-day RID (n = 79, rho = 0.49, p < 0.001), and after a 30-day RID (n = 46, rho = 0.73, p < 0.001). There was a significant decrease in UI after the RID. The median UI measurement was 275 mu g/l at baseline and 99 and 80 mu g/l after a 15-and 30-day RID, respectively. There was a significant increase in NIS expression after a 15-day RID. Conclusions: A 15-day RID is sufficient to deplete the iodine pool. sU can replace 24U UI as a marker for assessing the iodine pool. NIS expression was increased after a 15-day RID. (C) 2015 European Thyroid Association Published by S. Karger AG, Basel (AU)