Effects of metformin on bone healing around titanium implants inserted in non-diabetic rats

Autor(es)

Bastos, Marta Ferreira ^[1] ; Serrao, Caroline Ribeiro ^[1] ; Miranda, Tamires Szeremeske ^[1] ; Cruz, Daniele Ferreira ^[1] ; Malta, Fernando de Souza ^[1] ; Duarte, Poliana Mendes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Guarulhos, Dept Periodont, Dent Res Div, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical Oral Implants Research; v. 28, n. 10, p. E146-E150, OCT 2017.
• Citações Web of Science: 2

Resumo

ObjectiveTo evaluate the effects of metformin on bone healing around titanium implants inserted in non-diabetic rats. MethodsTwenty Wistar rats were randomly assigned to one of the following groups: control group (n=10): rats without metformin treatment; MT group (n=10): rats treated with metformin (40mg/kg/day by gavage). At thirty days after implant placement, animals were euthanized. Histometric measurements of bone-to-implant contact (BIC) and bone area (BA), in addition to immunohistochemical analysis of the number of cells stained for RANKL and OPG, were assessed in the cortical and medullary areas around implants. ResultsThe percentages of BIC and BA in the cortical bone were significantly lower in the MT group than in the control group (P<0.05). Furthermore, the medullary bone around the implants inserted in the metformin-treated animals exhibited an increased number of RANKL-stained cells than that around the implants inserted in the control animals (P<0.05). ConclusionsMetformin negatively affected osseointegration by reducing the percentages of BIC and BA and increasing the expression of RANKL around titanium implants inserted in non-diabetic rats. (AU)

• Processo FAPESP: 14/22074-9 - Efeito da metformina no tecido ósseo ao redor de implantes de titânio inseridos em tíbias de ratos: avaliações histométricas e imunohistoquímicas
• Beneficiário: Daniele Ferreira da Cruz
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/09628-2 - Impacto do diabetes tipo 2 e do tratamento com metformina na perda óssea induzida por ligadura, no reparo ósseo alveolar e na produção de citocinas ex vivo: estudo em ratos
• Beneficiário: Marta Ferreira Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Regular