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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of metformin on bone healing around titanium implants inserted in non-diabetic rats

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Author(s):
Bastos, Marta Ferreira [1] ; Serrao, Caroline Ribeiro [1] ; Miranda, Tamires Szeremeske [1] ; Cruz, Daniele Ferreira [1] ; Malta, Fernando de Souza [1] ; Duarte, Poliana Mendes [1]
Total Authors: 6
Affiliation:
[1] Univ Guarulhos, Dept Periodont, Dent Res Div, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Clinical Oral Implants Research; v. 28, n. 10, p. E146-E150, OCT 2017.
Web of Science Citations: 2
Abstract

ObjectiveTo evaluate the effects of metformin on bone healing around titanium implants inserted in non-diabetic rats. MethodsTwenty Wistar rats were randomly assigned to one of the following groups: control group (n=10): rats without metformin treatment; MT group (n=10): rats treated with metformin (40mg/kg/day by gavage). At thirty days after implant placement, animals were euthanized. Histometric measurements of bone-to-implant contact (BIC) and bone area (BA), in addition to immunohistochemical analysis of the number of cells stained for RANKL and OPG, were assessed in the cortical and medullary areas around implants. ResultsThe percentages of BIC and BA in the cortical bone were significantly lower in the MT group than in the control group (P<0.05). Furthermore, the medullary bone around the implants inserted in the metformin-treated animals exhibited an increased number of RANKL-stained cells than that around the implants inserted in the control animals (P<0.05). ConclusionsMetformin negatively affected osseointegration by reducing the percentages of BIC and BA and increasing the expression of RANKL around titanium implants inserted in non-diabetic rats. (AU)

FAPESP's process: 14/22074-9 - Effects of metformin on bone tissue around titanium implant inserted in tibiae of rats: histometric and immunohistochemistry evaluations
Grantee:Daniele Ferreira da Cruz
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/09628-2 - Impact of type 2 diabetes and metformin treatment on ligature-induced bone loss, alveolar bone healing and ex vivo cytokines production: study in rats
Grantee:Marta Ferreira Bastos
Support Opportunities: Regular Research Grants