Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development

Autor(es)

de Brito Guzzo Soliani, Flaviane Cristina ^[1] ; Cabbia, Rafael ^[1] ; Batistela, Matheus Fitipaldi ^[1] ; Almeida, Amarylis Garcia ^[1] ; Kumpel, Vinicius Dias ^[1] ; Yamauchi Junior, Luiz ^[1] ; Carneiro Spera de Andrade, Telma Goncalves ^[2]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Lab Physiol, Assis, SP - Brazil

^[2] UNESP Univ Estadual Paulista, Lab Physiol, Dept Biol Sci, Assis, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 12, n. 10 OCT 16 2017.
• Citações Web of Science: 0

Resumo

The multiple insecurities, anatomical, physiological and psychological changes arising from the gestational period can generate an overload of stress in the mother and cause disturbances in the offspring, affecting it throughout its development. The existing analysis linking prenatal stress and offspring's anxiety have divergent results, being limited as to gestational week, type of stressor and age of progeny's assessment. Social separation has been described as a stressor that causes increase in anxiety. Thus, the present study evaluated the effects of social separation applied in one of the three gestational weeks of rat dams on the manifestation of the defensive behaviors related to generalized anxiety disorder and panic in the Elevated T Maze of the male progeny in three stages of development (1, 3 or 6 months of life). It was found, in the offspring of grouped (control) dams, increased behaviors associated with generalized anxiety disorder and a reduction of panic-like behaviors throughout development. For animals whose dams were socially separated during pregnancy, the most critical period of exposure was the 2nd gestational week, which affected the acquisition of aversive memory, demonstrated by the impairment on learning of avoidances of the offspring in all ages evaluated. Stressor exposure in this week also increased the avoidances, related to generalized anxiety of progeny in the 1st month and decreased escapes, related to panic in the 3rd month of life and, at the age of 6 months old, an inverse situation, with the reduction of the defensive behaviors associated to generalized anxiety disorder. The results show that, when assessing effects of prenatal stress on the manifestation of anxiety, not only the period of exposure is important, but also the age of offspring assessed. (AU)

• Processo FAPESP: 13/10808-5 - Efeito de estressores sobre o perfil de ansiedade em fêmeas na prenhez e no puerpério
• Beneficiário: Rafael Cabbia
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/19973-6 - Efeito do estresse pré-natal sobre a manifestação da ansiedade na idade adulta, no labirinto em T elevado
• Beneficiário: Flaviane Cristina de Brito Guzzo Soliani
• Modalidade de apoio: Bolsas no Brasil - Mestrado