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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The evolution of phenotypic integration: How directional selection reshapes covariation in mice

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Autor(es):
Penna, Anna [1] ; Melo, Diogo [1] ; Bernardi, Sandra [2] ; Oyarzabal, Maria Ines [3, 4] ; Marroig, Gabriel [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Lab Evolucao Mamiferos, Dept Genet & Biol Evolut, Inst Biociencias, Sao Paulo - Brazil
[2] Univ Nacl Rosario, Fac Ciencias Vet, Catedra Histol & Embriol Basica, Rosario, Santa Fe - Argentina
[3] Univ Nacl Rosario, Fac Ciencias Vet, Catedra Prod Bovinos Carne, Rosario, Santa Fe - Argentina
[4] Univ Nacl Rosario, Consejo Invest, Rosario, Santa Fe - Argentina
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Evolution; v. 71, n. 10, p. 2370-2380, OCT 2017.
Citações Web of Science: 9
Resumo

Variation is the basis for evolution, and understanding how variation can evolve is a central question in biology. In complex phenotypes, covariation plays an even more important role, as genetic associations between traits can bias and alter evolutionary change. Covariation can be shaped by complex interactions between loci, and this genetic architecture can also change during evolution. In this article, we analyzed mouse lines experimentally selected for changes in size to address the question of how multivariate covariation changes under directional selection, as well as to identify the consequences of these changes to evolution. Selected lines showed a clear restructuring of covariation in their cranium and, instead of depleting their size variation, these lines increased their magnitude of integration and the proportion of variation associated with the direction of selection. This result is compatible with recent theoretical works on the evolution of covariation that take the complexities of genetic architecture into account. This result also contradicts the traditional view of the effects of selection on available covariation and suggests a much more complex view of how populations respond to selection. (AU)

Processo FAPESP: 11/14295-7 - Modularidade e suas consequências evolutivas
Beneficiário:Gabriel Henrique Marroig Zambonato
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/06577-8 - Integração morfológica no crânio de Lemuriformes (Primates: Strepsirrhini)
Beneficiário:Anna Paula Casselli Penna
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 14/26262-4 - Estimativas diretas de parâmetros evolutivos via análise de loci de traços quantitativos
Beneficiário:Diogo Amaral Reboucas Melo
Linha de fomento: Bolsas no Brasil - Doutorado